Transcend Sarcoma Donate £25K to UCL to help the Foundation Clear Cell Sarcoma Research

Transcend Sarcoma, is a charity set up by Jack Holmes, who sadly died of a rare “translocational” sarcoma in October 2024. Clear Cell Sarcoma is also a translocational sarcoma.

Transcend Sarcoma is kindly donating £25,000 to the Sarcoma Genomics Lab at UCL to be used on the Edward Showler CCS programme.

“The first project we have chosen to support focuses on understanding the role of a rare type of cancer protein caused by two pieces of DNA becoming fused (fusion gene or translocation) to each other. The new fusion protein has properties that cause cancer and is only found in tumour cells and not in normal healthy cells. This research is part of a larger initiative aimed at developing and testing a new class of drugs known as ‘Proteolysis Targeting Chimeras’ (“PROTACs”). These innovative drugs are designed to degrade the fusion proteins, thereby killing the cancer cells and leaving the healthy cells unharmed. This approach offers the potential to develop groundbreaking treatments for sarcomas driven by translocations.”

We would like to thank the family, friends and supporters of Transcend Sarcoma for their kindness and generosity and look forward to building a strong working relationship with them.